Why it is important study quiescent cancer stem cells Essay

Why it is important study quiescent cancer stem cells - Essay ExampleThe study done by Dembinski and Krauss (2009) gave a dense evidence of linkages between quiescence and cancer stem cells.Moreover, the study of quiescence CSCs is important for the reason that the quiescent cancer stem cells are found to be resistant to chemotherapy and other applied therapies (Moore 2010). It has been discovered that as soon as the therapy is discontinued, they retain their plead. In this perspective, it becomes necessary to understand the mechanisms of stem cell quiescent state so that normal stem cell functionality could be manipulated. The understanding on this account helps develop the clinical approaches to quell and tar frig around cancer stem cells. As per Li (2011), the recent findings explain the resistance of cancer stem cells by their state of dormancy. Dormant cancer stem cells can be activated by altering their intrinsic or extrinsic mechanisms that tend to maintain their quiescent s tate so that they become susceptible to the applied chemotherapy and help discover hot visions in the cancer treatment.From above it is quite clear that the study of quiescence CSCs is likely to open new vistas in the discovery of new cancer drugs and therapies to get effective and lasting treatment for all kinds of cancers.1. Moore N. Lyle, S. (2010),Quiescent, Slow-Cycling Stem Cell Populations in Cancer A Review of the Evidence and Discussion of Significance, Online at http//www.ncbi.nlm.nih.gov/pmc/articles/PMC2948913/sec6 Accessed 23 October 20113. Roesch A, Fukunaga-Kalabis M, et al (2010). A temporarily distinct subpopulation of behindhand-cycling melanoma cells is required for continuous tumor growth. Cell., 141(4)583594. Also online at http//www.ncbi.nlm.nih.gov/pmc/articles/PMC2882693/ Accessed 23 October 20114. Dembinski JL, Krauss S. (2009), Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma, Clinical and Experimental Metastasis, 26 (7)611623.